Lion’s Mane

Cognitive Function

In a double-blind, placebo-controlled clinical trial of thirty 50-80 year old Japanese adults diagnosed with middle cognitive impairment, oral intake of Hericium erinaceus 250 mg tablets (96% dry powder) three times a day for 16 weeks was associated with marked improvement in the revised Hasegawa Dementia Scale (HDS-R) as compared to controls.

Scores on the HDS-R decreased, however, by 4 weeks after cessation of the intervention.¹

Alzheimer's Disease

The Alzheimer’s Drug Discovery Foundation (Cognitive Vitality.org) also reports that:

One open-label study described in a review (Kawagishi 2008) followed 7 patients diagnosed with Alzheimer’s disease or cerebrovascular dementia that were given 5 grams of lion’s mane powdered mushroom in their soup, daily for 6 months.

According to the review, 6 out of 7 patients had improvements in their perceptual capacity, while all 7 patients showed improvements in functional independence. 3 bedridden patients were able to get up for meals after treatment.”²

Anxiety and Depression

In a clinical trial, Hericium erinaceus fruiting body administered in cookies at 2 grams per day over 4 weeks showed a reduction in some symptoms of anxiety and depression in menopausal women (n=30).

For the women taking the treatment (as compared to placebo), the Indefinite Complaints Index categories for Palpitation and Incentive showed statistically significant improvement and the categories of Irritating, Anxious and Concentration indicated a trend in the direction of improvement.³

Reishi – Ganoderma lucidum

General Health:

A report of several randomized, double-blind, multi-centered, placebo-controlled clinical trials on reishi showed benefit, not only in type II diabetes, but also improved symptoms of coronary heart disease, neurasthenia and chronic hepatitis B infections.⁴

Improved Emotional and Cognitive Functioning

A pilot randomized clinical trial with 48 breast cancer patients with cancer-related fatigue undergoing endocrine therapy delivered 1000 mg ofGanoderma lucidumspore powder three times daily for 4 weeks.

Compared to the control group, significant increases in overall quality of life and physical function were observed in treated individuals, as well as equally significant improvement in emotion and functional well-being, state of depression and anxiety, emotional functioning, cognitive function, and symptoms like fatigue, sleep disturbance, and appetite loss.”

Anxiety and Depression

In a randomized, double-blind, placebo-controlled clinical trial of 132 neurasthenic patients, subjects receiving 1800 mg of Ganoderma lucidum three times daily for 8 weeks “were found to have an increased sense of well-being as measured by the Visual Analogue Scale (VAS), and consistent reductions in the Clinical Global Impression (CGI) severity scale score and fatigue.”

Respiratory Symptoms

A reishi syrup was given to over two thousand patients suffering chronic bronchitis, with a 60%-90% improvement in just two weeks. Older patients, especially those with bronchial asthma, responded favorably.⁹

Ready to improve your health?

Our proprietary mushroom blend of pure Reishi and Lion's Mane mushroom extracts can be found in all our delicious products, click below to choose from drinks, oatmeal and easy to use capsules.

REFERENCES
  1. Mori K, Inatomi S, Ouchi K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009; 23:367-72. Quoted in Neurological Activity of Lion’s Mane (Hericium erinaceus) Kevin Spelman, PhD, MCPP, Elizabeth Sutherland, ND, Aravind Bagade, MD, Journal of Restorative Medicine 2017; 6: pg 19.
  2. Cognitive Vitality.Org report, written by neuroscientists at the Alzheimer’s Drug Discovery Foundation, last updated September 8, 2016, Lion’s Mane Mushroom. Quoting review by Kawagishi,H.; Zhuang,C. Compounds for dementia from Hericium erinaceum. Drugs Future 2008, 33, 149-155.
  3. Nagamo M, Shimizu K, Kondo R, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010;31:231-7. Quoted in Neurological Activity of Lion’s Mane (Hericium erinaceus) Kevin Spelman, PhD, MCPP, Elizabeth Sutherland, ND, Aravind Bagade, MD, Journal of Restorative Medicine 2017; 6: pg 19.
  4. Zhou, S., Y.Gao, E.Chan. 2005. Clinical Trials for medicinal mushrooms: experience with the Ganoderma lucidum (W.Curt:Fr.) Lloyd (Lingzhi mushroom). International Journal of Medicinal Mushrooms 7(2): 111-118.
  5. Venturella G, Ferraro V, Cirlincione F, Gargano M. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. International Journal of Molecular Sciences, 2021, 22, 634, pg 16, quoting the following clinical trial: Zhao,H.; Zhang,Q.; Zhao.L.; Huang,X.; Wang, J.; Kang,X. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A pilot clinical trial. Evid. Based Complementary Altern. Med. 2012, 809614.
  6. Gao Y et al. 2004a. A phase I/II study of ling zhi mushroom Ganoderma lucidum extract in patients with type II diabetes mellitus. International Journal of Medicinal Mushrooms 6(1): 33-40, quoted in Robert Dale Rogers RH (AHG), Medicinal Mushrooms The Human Clinical Trials, 2020, WMC Publishing.com, pgs 48, 56.
  7. Venturella G, Ferraro V, Cirlincione F, Gargano M. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. International Journal of Molecular Sciences, 2021, 22, 634, pg 8, quoting the following clinical trial: Tang, W.; Gao,Y.; Chen,G.; Gao,H.; Dai,X.; Ye J.; Chan,E.; Huang M.; Zhou,S. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food. 2005, 8, 53-58.
  8. Venturella G, Ferraro V, Cirlincione F, Gargano M. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. International Journal of Molecular Sciences, 2021, 22, 634, pg 15, quoting the following clinical trial: Gao,Y.; Dai,X.; Chen G.; Ye,J.; Zhou,S. A randomized, placebo-controlled, multicenter study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae polysaccharides (Ganopoly) in patients with advanced lung cancer. Int. J. Med. Mushrooms, 2003, 5, 369-382.
  9. Chang HM & But PPH Editors. 1987. Pharmacology and Applications of Chinese Materia Medica Volume 2. Mainland Press. Singapore. Quoted from Robert Dale Rogers RH (AHG), Medicinal Mushrooms The Human Clinical Trials, 2020, WMC Publishing.com, pgs 47, 119.
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