Here's just some of the science:

  • Lion’s Mane has been shown to have various health benefits, including anti-oxidative, anti-diabetic, anticancer, anti-inflammatory and anti-hyperglycaemic effects. It has been used to treat cognitive impairment, Parkinson’s Disease and Alzheimer’s disease. It contains bioactive compounds that have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. ¹

  • Many studies demonstrate that the fruiting body extracts from Lion’s Mane mushrooms induce statistically significant improvement in spatial short-term and recognition memory, locomotion performance, neurotransmission and neurogenesis in aged mice.²

  • In a double-blind, placebo-controlled clinical trial of 50-80 year old Japanese adults diagnosed with mild cognitive impairment, daily 750mg doses of Lion’s Mane for 16 weeks showed marked improvement in the Hasegawa Dementia Scale.³

Oxidative stress and inflammation are key factors causing neurodegenerative diseases like Alzheimer’s and Parkinson’s.

The hericinones from the fruiting body of Lion’s Mane mushrooms, extracted in hot water and alcohol, showed potent neuro-protective properties in vitro studies, protecting our brains by increasing neural antioxidants and mitochondrial function and reducing apoptosis (cell death).⁴

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REFERENCES

1. Chong.PS et al. Therapeutic Potential of Hericium erinaceus for Depressive Disorder, Int.J.Mol.Sci. 2020, 21, 163; doi:10.3390/ijms2101016

2. Neuroprotective Metabolites of Hericium erinaceus Promote Nuero-Healthy Aging (Int.J.Mol.Sci. 2020, 21, 163; doi:10.3390/ijms21010163); Brandalise F et al. Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evid.-Based Complement. Altern. Med. 2017,3864340; Corona F et al. Array of Metabolites in Italian Hericium erinaceus Mycelium, Promordium and Sporophore. Molecules 2019, 24, 3511; Lai et al. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms, 2013; 15(6)

3. Mori K et al. Improving Effects of the mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23:367-72

4.  Kushairi et al. Lion’s Mane Mushroom Suppresses H202 Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia; Antioxidants 2019, 8, 261.

5. Spelman K Phd et al. Neurological Activity of Lion’s Mane (Hericium erinaceus). Journal of Restorative Medicine 2017; 6:24

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